Obesity & Serotonin

Obesity & Serotonin
It is increasingly recognized that obesity is not a failure of will or behaviour, nor is it a disorder of body weight regulation. It is a chronic medical condition, like hypertension or diabetes.In the obese person, body weight is just as carefully regulated as it is in non obese persons, but regulation is around an elevated set point. This homeostatic set point — strongly influenced by genetics and is probably controlled by neurotransmitters that signal hunger or signal satiety.Only those individuals with exceptional will power and the ability to tolerate discomfort are able to defeat this homeostatic mechanism through dietary energy restriction.
A number of major studies have shown that the majority of dieters who lose weight with low-calorie diets and behaviour modification regain that lost weight within 3 to 5 years.
If eating behaviour, like mood and personality, is simply the result of a mixture of neurotransmitters, then a pharmaceutical intervention may be more effective than attempts at behaviour modification, just as antidepressants are generally more effective for clinical depression than a psychiatrist.At one time, amphetamines were being used for weight control, although when the drug was discontinued, the patient gained back all the lost weight. However, if obesity is a chronic medical condition in the same way that hypertension is a chronic medical condition, then weight gain following drug discontinuation is no different from rising blood pressure after the discontinuation of antihypertensive medications.
Using serotonin reuptake inhibitors for weight lossIn the early 1980s, clinical investigators discovered a link between serotonin and eating disorders. The discovery was unexpected: during clinical trials of the serotonin reuptake-inhibitor fluoxetine, one side effect noted was weight loss. Even before this, seotonin was implicated in the eating disorders.

The dietary starch is converted to sugar, sugar stimulates the pancreas to release insulin, insulin raises brain levels of the amino acid tryptophan, tryptophan is a precursor of serotonin, and serotonin regulates mood, producing a sense of well-being. Therefore, obese people load up on carbohydrates to elevate mood. In studies with obese women, it was found that a high-carbohydrate snacks improved mood.

Subsequent studies showed that serotoninergics helped overeaters lose weight. One agent — dexfenfluramine — was particularly effective for cutting food intake. Dexfenfluramine is the active portion of the anti-obesity agent fenfluramine. Its side effects are dry mouth, diarrrhea, unsteadiness, and memory problems along with cardiac problems..

Because of the seriousness of the valvular heart disease associated with the use of fenfluramine, the medication was withdrawn from the market in September of 1997

According to the National Institutes of Health and the Centers for Disease Control, more than 30% of Americans are 20% or more overweight, and one third of women and more than one quarter of men are trying to lose weight at any given time.

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About Manbir & Gurpreet

Gurpreet Kaur’s journey in this world .... Gurpreet Kaur was a Musician. She was a singer and a composer of music. Her interest was composing and singing Gurbani Shabads in Indian Classical style. She sang Shabads in All the Raags mentioned in Sri Guru Granth Sahib Ji. She also taught Gurmat Sangeet at Gurmat Gian Missionary College, Jawadi, Ludhiana. Elder child to Pushpinder Kaur and Dr. Brig. Harminder Singh, was born in Amritsar on 13th Jan 1962. She attended various convent schools as a child because her father would get frequent Army postings as a dental surgeon. She graduated with Music Honors from Govt. College for Women, Chandigarh. Music was her hobby and she composed and sang Raag based Gurbani Shabads. Doing Kirtan was part of growing up nurtured by her parents. She learned music from her father Dr. Brigadier Harminder Singh who was a dental surgeon in Indian Army and a very good singer himself. Gurpreet’s Bhua (father’s sister), Ajit Kaur retied as a Head of Department of Music from Govt. College for Women Ludhiana, and was a renounced Punjabi singer of her time. Gurpreet Kaur also learned nuances of Indian Classical Music from Pandita Sharma. She was a mother of three children, and a grandmother. Her daughter Keerat Kaur is a Computer Engineer. Her two sons Gurkeerat Singh and Jaskeerat Singh are doctors in USA. Her daughter Keerat Kaur too was part of her group ~ Gurmat Gian Group. Gurpreet Kaur left this world at the age of 54yrs on 12th Sept 2016 in Baltimore USA. She had recorded around 25 cds of Gurbani Keertan. 'Raag Ratan' Album (6 CDs) is a Compilation of Shabads in All the 31 Sudh Raags of Sri Guru Granth Sahib Ji. 'Gauri Sagar' Album (3 CDs) is a Compilation of All forms of Raag Gauri in Sri Guru Granth Sahib Ji. 'Nanak Ki Malhaar' ~ ((3 CDs) is an album of Raag Malhar Shabads in various forms of Malhar. 'Gur Parsaad Basant Bana' ~ (3 CDs) is an album of Shabads in Raag Basant sung in various forms of Raag Basant. Har Ki Vadeyai Sarni Aayea Sewa Priya Kee Preet Piyaree Mohan Ghar Aavho Karo Jodariya Mo Kao Taar Le Raama Taar Le Tere Kavan Kavan Gun Keh Keh Gawan Mera Baid Guru Govinda Saajanrraa Mera Saajanrraa

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