Short Stature ~ Cause

Causes of Short Stature
Short Stature is a comparative evaluation of an individual’s height with his genetic background and in relation to that of a large population of a similar genetic background. Growth Failure and Short Stature may not be the same thing. Often these two are confused as the same thing. Short stature is often a normal variant. On the other hand Short Stature may be a sign of a wide variety of pathologic conditions or inherited disorders.
Majority of patients with Short Stature come under following groups:

  • Constitutional Growth Delay – 98 %
  • Growth Hormone deficiency – 0.1 %
  • Hypothyroidism – 0.2 %
  • Systemic diseases – 0.3 %
  • Chromosomal disorders – 0.1 %
  • Bone Cartilage Dysplasia – 0.3 %
  • Psycho social disorders – 1 %
Important Causes of Short Stature

  • Isolated GH deficiency
  • Panhypopituitarism
  • Primary hypothyroidism
  • Cushing’s syndrome
  • Achondroplasia- short limbs for spine
  • Mucopolysaccharidoses- short limbs and very short spine.
  • Turner’s syndrome
  • Malabsorption syndromes- Crohn’s disease,Coeliac disease, Colitis
  • Congenital heart diseases, Intrauterine growth retardation,Systemic illnesses like asthma, renal disease, malnutrition, psychosocial deprivation, Constitutional short stature with normal bone age.
Clinically, syndromes of Short Stature present with specific physical findings which may aid in diagnosing the illness, like –Growth Hormone deficiency – Frontal bossing, Central Obesity, High pitched voice.
Hypothyroidism – Dry skin, coarse hairs, immature facies
Cushing syndrome – Striae, central obesity, hypertension
Gonadal dysgenesis – Delayed sexual development, webbed neck, multiple pigmented navi, shield chest
Pseudohypoparathyroidism – Mental retardation, moon facies, obesity, short metacarpals.
Bone Cartilage dysplasia – Abnormal proportions, macrocephaly
Russell Silver Dwarfism – Small at birth, pointed facies, asymmetry
To reach the final diagnosis regarding the cause of the short stature in an individual detailed history and clinical examination is important followed by some screening tests which may pin point the actual cause of short stature.

Some of these test are –
Serum thyroxine – hypothyroidism
Serum GH levels – Growth hormone deficiency
Serum calcium – Pheusohypoparathyroidism
Serum phosphate – Vitamine D resistant Rickets
Serum bicabonate – Renal tubular acidosis
Blood urea nitrogen – Renal failure
Complete Blood count – Anaemia, nutritional disorders, inflammatory diseases
Bone age – Hypothyroidism, GH deficiency, Constitutional delay
Chromosomal karyotype – Gonadal dysgenesis and other abnormalities


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About Manbir & Gurpreet

Gurpreet Kaur’s journey in this world .... Gurpreet Kaur was a Musician. She was a singer and a composer of music. Her interest was composing and singing Gurbani Shabads in Indian Classical style. She sang Shabads in All the Raags mentioned in Sri Guru Granth Sahib Ji. She also taught Gurmat Sangeet at Gurmat Gian Missionary College, Jawadi, Ludhiana. Elder child to Pushpinder Kaur and Dr. Brig. Harminder Singh, was born in Amritsar on 13th Jan 1962. She attended various convent schools as a child because her father would get frequent Army postings as a dental surgeon. She graduated with Music Honors from Govt. College for Women, Chandigarh. Music was her hobby and she composed and sang Raag based Gurbani Shabads. Doing Kirtan was part of growing up nurtured by her parents. She learned music from her father Dr. Brigadier Harminder Singh who was a dental surgeon in Indian Army and a very good singer himself. Gurpreet’s Bhua (father’s sister), Ajit Kaur retied as a Head of Department of Music from Govt. College for Women Ludhiana, and was a renounced Punjabi singer of her time. Gurpreet Kaur also learned nuances of Indian Classical Music from Pandita Sharma. She was a mother of three children, and a grandmother. Her daughter Keerat Kaur is a Computer Engineer. Her two sons Gurkeerat Singh and Jaskeerat Singh are doctors in USA. Her daughter Keerat Kaur too was part of her group ~ Gurmat Gian Group. Gurpreet Kaur left this world at the age of 54yrs on 12th Sept 2016 in Baltimore USA. She had recorded around 25 cds of Gurbani Keertan. 'Raag Ratan' Album (6 CDs) is a Compilation of Shabads in All the 31 Sudh Raags of Sri Guru Granth Sahib Ji. 'Gauri Sagar' Album (3 CDs) is a Compilation of All forms of Raag Gauri in Sri Guru Granth Sahib Ji. 'Nanak Ki Malhaar' ~ ((3 CDs) is an album of Raag Malhar Shabads in various forms of Malhar. 'Gur Parsaad Basant Bana' ~ (3 CDs) is an album of Shabads in Raag Basant sung in various forms of Raag Basant. Har Ki Vadeyai Sarni Aayea Sewa Priya Kee Preet Piyaree Mohan Ghar Aavho Karo Jodariya Mo Kao Taar Le Raama Taar Le Tere Kavan Kavan Gun Keh Keh Gawan Mera Baid Guru Govinda Saajanrraa Mera Saajanrraa

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