Pemphigus Vulgaris

Pemphigus Vulgaris
Pemphigus is a group of rare autoimmune blistering disorders of the skin in which blisters and sores occur in skin and mucous membrane. It is a disease of immune system. The immune system produces antibodies which normally attack hostile viruses and bacteria in the blood in an effort to keep us healthy. In an affected individual however, the antibodies erroneously perceive the skin and/or mucous membrane tissue as foreign and attacks them. This produces burn-like lesions that will not heal. In some cases, these sores can cover a significant area of the skin. The disease can give a horrifying image and if not managed properly may lead to death. There is no cure for this disease. Steroids are only hope and give dramatic relief.
There are three main categories of Pemphigus.Paraneoplastic Pemphigus, Pemphigus vulgaris and Pemphigus foliaceusPemphigus vulgarisIt is most frequently diagnosed form of pemphigus. Sores and blisters almost always start in the mouth. Large bullae occur on skin. Those in the oral cavity soon rupture leaving a ragged slough over a shallow ulcer. It has a high rate of mortality.

There is a research which shows that there is a genetic predisposition to Pemphigus Vulgaris, based primarily on the observation that this disease appears to occur more frequently than normal in Askenazi Jews.

Microscopic Features: Characteristic features under microscope are “Intraepithelial clefting” and “tombstoning”.

 Pemphigus Vulgaris
Pemphigus foliaceusWith pemphigus foliaceus, blisters and sores do not occur in the mouth. Crusted sores or fragile blisters usually first appear on the face and scalp and later involve the chest and back.The blisters are superficial and often itchy, but are not usually as painful as in pemphigus vulgaris. In PF disfiguring skin lesions can occur but the mortality rate from the disease is much lower than in PV  Pemphigus Vulgaris
Paraneoplastic pemphigusThis is the most serious form of pemphigus, which occurs most often in someone who has already been diagnosed with a Cancer.

 Paraneoplastic Pemphigus


Prednisone is the most important medication for these patients and those not put on steroids may rapidly deteriorate and die. Dose of prednisone has to be according to the need of individual patient. Other drugs used include Azathioprine, CyclophosphamideMethotrexate, Dapsone, GoldTetracyclineMinocycline.

Diet high in protein, low in carbohydrates, low in salt, low in fat is beneficial. In extensive lesions fluid loss may have to be managed. Mouth lesions may hamper nutrition of the patient which also has to be taken care of. Blood calcium and potassium levels may be disturbed. Fungal infections have also to be managed in such patients.

 Skin Diseases
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About Manbir & Gurpreet

Gurpreet Kaur’s journey in this world .... Gurpreet Kaur was a Musician. She was a singer and a composer of music. Her interest was composing and singing Gurbani Shabads in Indian Classical style. She sang Shabads in All the Raags mentioned in Sri Guru Granth Sahib Ji. She also taught Gurmat Sangeet at Gurmat Gian Missionary College, Jawadi, Ludhiana. Elder child to Pushpinder Kaur and Dr. Brig. Harminder Singh, was born in Amritsar on 13th Jan 1962. She attended various convent schools as a child because her father would get frequent Army postings as a dental surgeon. She graduated with Music Honors from Govt. College for Women, Chandigarh. Music was her hobby and she composed and sang Raag based Gurbani Shabads. Doing Kirtan was part of growing up nurtured by her parents. She learned music from her father Dr. Brigadier Harminder Singh who was a dental surgeon in Indian Army and a very good singer himself. Gurpreet’s Bhua (father’s sister), Ajit Kaur retied as a Head of Department of Music from Govt. College for Women Ludhiana, and was a renounced Punjabi singer of her time. Gurpreet Kaur also learned nuances of Indian Classical Music from Pandita Sharma. She was a mother of three children, and a grandmother. Her daughter Keerat Kaur is a Computer Engineer. Her two sons Gurkeerat Singh and Jaskeerat Singh are doctors in USA. Her daughter Keerat Kaur too was part of her group ~ Gurmat Gian Group. Gurpreet Kaur left this world at the age of 54yrs on 12th Sept 2016 in Baltimore USA. She had recorded around 25 cds of Gurbani Keertan. 'Raag Ratan' Album (6 CDs) is a Compilation of Shabads in All the 31 Sudh Raags of Sri Guru Granth Sahib Ji. 'Gauri Sagar' Album (3 CDs) is a Compilation of All forms of Raag Gauri in Sri Guru Granth Sahib Ji. 'Nanak Ki Malhaar' ~ ((3 CDs) is an album of Raag Malhar Shabads in various forms of Malhar. 'Gur Parsaad Basant Bana' ~ (3 CDs) is an album of Shabads in Raag Basant sung in various forms of Raag Basant. Har Ki Vadeyai Sarni Aayea Sewa Priya Kee Preet Piyaree Mohan Ghar Aavho Karo Jodariya Mo Kao Taar Le Raama Taar Le Tere Kavan Kavan Gun Keh Keh Gawan Mera Baid Guru Govinda Saajanrraa Mera Saajanrraa

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