Role of Oestrogen in Osteoporosis

Role of Oestrogen in Osteoporosis
The Role of Hormone Therapy in the Prevention and Treatment of OsteoporosisWhile one in four women over the age of 50 has osteoporosis, only one in eight men have the disease. This striking difference is largely due to the important role which the sex hormones (primarily estrogen) play in keeping women’s bones healthy.
Bone is a living tissue that is constantly renewed through a process in which old bone is removed and replaced by new bone. In Bone there are two important types of cells – Osteoblasts and Osteoclasts. Osteoclasts are bone eroding cells and Osteoblasts are bone forming cells. The bone eroding cells invade the bone and erode it creating cavities in the bone and the bone forming cells fill the cavities with new bone. This is a natural process — nature’s way of restoring bones and keeping them strong.
In younger persons with good bone health, both the cells that erode bone and those that build bone work together. But as we age the bone builders are unable to keep pace with the bone excavators, and this results in loss of bone.
Estrogen has been found to play a major role in maintaining the balance by slowing the pace of bone erosion. When a woman’s estrogen levels fall dramatically, bone loss is accelerated.
During Menopause, a woman’s estrogen significantly decreases as her ovaries  where nearly all estrogen is produced, cease to function. A woman can lose 2 to 5 % of her bone density each year during the first 5 to 10 years following menopause. However, not all women develop osteoporosis despite this accelerated bone loss. For example, a woman who enters menopause with a high bone density will be less likely to develop osteoporosis because she has more bone to start with. Other factors are also important including genetics, physical activity and nutrition.
Early Menopause
The relationship between bone health and estrogen raises great concern in women who experience premature menopause — menopause before the age of 45. Sometimes such a menopause occurs naturally, while other times it is medically induced through surgery or chemotherapy. Whatever the cause, early menopause can lead to significant bone loss.
Amenorrhea (Missed Periods)
Amenorrhea is a condition which can develop when a girl or young woman develops an eating disorder or when she is training in sports or other intensive physical activities where she over-exercises. In such cases her menstrual cycle may be disrupted and her estrogen production will decrease.
Periods of estrogen loss during this time of life — even if temporary — can have a profound effect on a woman’s bone health over her lifetime.
As a result, even if she does not develop osteoporosis early in life, she will reach menopause at a great disadvantage and be a likely candidate for postmenopausal osteoporosis.
Estrogen Halts Bone Loss
If used early enough this can prevent a woman’s bones from becoming osteoporotic. In cases where she has low bone density or has already fractured, estrogen can stabilize or even improve her bone density.
Research has provided enough evidence to make a strong case for the use of estrogen as both a preventive therapy and as a treatment for established osteoporosis.


This entry was posted in Medical Tidbits and tagged , by Manbir & Gurpreet. Bookmark the permalink.

About Manbir & Gurpreet

Gurpreet Kaur’s journey in this world .... Gurpreet Kaur was a Musician. She was a singer and a composer of music. Her interest was composing and singing Gurbani Shabads in Indian Classical style. She sang Shabads in All the Raags mentioned in Sri Guru Granth Sahib Ji. She also taught Gurmat Sangeet at Gurmat Gian Missionary College, Jawadi, Ludhiana. Elder child to Pushpinder Kaur and Dr. Brig. Harminder Singh, was born in Amritsar on 13th Jan 1962. She attended various convent schools as a child because her father would get frequent Army postings as a dental surgeon. She graduated with Music Honors from Govt. College for Women, Chandigarh. Music was her hobby and she composed and sang Raag based Gurbani Shabads. Doing Kirtan was part of growing up nurtured by her parents. She learned music from her father Dr. Brigadier Harminder Singh who was a dental surgeon in Indian Army and a very good singer himself. Gurpreet’s Bhua (father’s sister), Ajit Kaur retied as a Head of Department of Music from Govt. College for Women Ludhiana, and was a renounced Punjabi singer of her time. Gurpreet Kaur also learned nuances of Indian Classical Music from Pandita Sharma. She was a mother of three children, and a grandmother. Her daughter Keerat Kaur is a Computer Engineer. Her two sons Gurkeerat Singh and Jaskeerat Singh are doctors in USA. Her daughter Keerat Kaur too was part of her group ~ Gurmat Gian Group. Gurpreet Kaur left this world at the age of 54yrs on 12th Sept 2016 in Baltimore USA. She had recorded around 25 cds of Gurbani Keertan. 'Raag Ratan' Album (6 CDs) is a Compilation of Shabads in All the 31 Sudh Raags of Sri Guru Granth Sahib Ji. 'Gauri Sagar' Album (3 CDs) is a Compilation of All forms of Raag Gauri in Sri Guru Granth Sahib Ji. 'Nanak Ki Malhaar' ~ ((3 CDs) is an album of Raag Malhar Shabads in various forms of Malhar. 'Gur Parsaad Basant Bana' ~ (3 CDs) is an album of Shabads in Raag Basant sung in various forms of Raag Basant. Har Ki Vadeyai Sarni Aayea Sewa Priya Kee Preet Piyaree Mohan Ghar Aavho Karo Jodariya Mo Kao Taar Le Raama Taar Le Tere Kavan Kavan Gun Keh Keh Gawan Mera Baid Guru Govinda Saajanrraa Mera Saajanrraa

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s