Botulism

Botulism

Botulism is a disease that occasionally strikes people who eat badly canned food or fish in which the bacteria has grown. The bacteria for botulism are also found in soil. The bacteria produce an extremely toxic substance, botulinum that causes blurred vision, dry mouth, difficulty in swallowing or speaking, weakness, paralysis, respiratory failure and death.

The organism causing this disease is Clostridium botulinum.

The disease may be classified as

(1) food-borne botulism, from ingestion of preformed toxin in food contaminated with C. botulinum
(2) wound botulism, from toxin produced in wounds contaminated with the organism
(3) infant botulism, from ingestion of spores and production of toxin in the intestine of infants

C. botulinum, is a group of anaerobic gram-positive organisms that form spores, is found in soil and marine environments throughout the world and produces the most potent bacterial toxin known. These are all neurotoxins.

Toxin can be inactivated during home cooking by exposure to a temperature of 100°C for 10 min. In the gastrointestinal tract, toxin resists degradation. Spores are highly heat-resistant, and their inactivation requires exposure to a temperature of 120°C (e.g., in steam sterilizers or pressure cookers).

Clinical Features

Food-Borne Botulism

After ingestion of food containing toxin, the illness may be a mild condition for which no medical advice is sought or it may also be a very severe disease that can result in death within 24 h. The onset of symptoms is with Cranial nerve involvement, which produces

  • diplopia – double vision
  • dysarthria – difficulty in speech
  • dysphagia – difficulty in swallowing

Weakness progresses, often rapidly, from the head to involve the neck, arms, thorax, and legs. The weakness is mostly symmetrical but may occasionally be asymmetric. Nausea, vomiting, and abdominal pain may precede or follow the onset of paralysis.

Patients are generally alert and oriented, but they may be drowsy, agitated.

Ptosis (drooping of eyelids) is frequent. Fixed or dilated pupils are noted in half of patients.

Paralytic ileus, severe constipation, and urinary retention may be present.

Wound Botulism

When wounds are contaminated with C. botulinum spores, the spores may germinate into vegetative organisms that produce toxin. This rare condition resembles food-borne illness except that the incubation period is longer, averaging about 10 days, and gastrointestinal symptoms are lacking. Wound botulism has been seen after traumatic injury involving contamination with soil, in chronic drug abusers, and after cesarean delivery. The illness has occurred even after antibiotics have been given to prevent wound infection. The wound may appear benign.

Infant Botulism

In infant botulism the most common form of the disease the Toxin is produced in and absorbed from the intestine after the germination of ingested spores. The severity ranges from mild illness with failure to thrive to fulminant severe paralysis with respiratory failure and may be one cause of sudden infant death. Contamination of honey with spores has been found to be one of the causes. This has led to the recommendation that honey not be fed to children less than 12 months of age. Most cases cannot be attributed to a particular food source. Cases usually involve infants less than 6 months of age.

There is another group in which the disease resembles the infant botulism in that the  toxin is produced in the intestine of a person colonized with the organism. In such cases the toxin and the spores may be found in the stool for a prolonged period. Gastrointestinal disease or surgery may predispose to such an illness.

DIAGNOSIS

A diagnosis of botulism is suspected in a person a febrile ( no fever ), mentally intact patients who have symmetric descending paralysis without sensory findings.

Conditions often confused with botulism include myasthenia gravis and Guillain-Barre syndrome, which is characterized by ascending paralysis, sensory abnormalities, and elevation of the protein concentration in cerebrospinal fluid. Other conditions resembling botulism are Lambert-Eaton syndrome, poliomyelitis, tick paralysis, diphtheria, and intoxications from mushrooms, medications, or chemicals.

PROGNOSIS

Mortality in botulism is higher among patients above age 60 than among younger patients. With improved respiratory and intensive care, the case-fatality rate in food-borne illness has been reduced.

BOTULINUM TOXIN THERAPY

Botulinum toxin is being used as therapy for strabismus, blepharospasm, and other dystonias.

Botox

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This entry was posted in Diseases & Conditions and tagged by Manbir & Gurpreet. Bookmark the permalink.

About Manbir & Gurpreet

Gurpreet Kaur’s journey in this world .... Gurpreet Kaur was a Musician. She was a singer and a composer of music. Her interest was composing and singing Gurbani Shabads in Indian Classical style. She sang Shabads in All the Raags mentioned in Sri Guru Granth Sahib Ji. She also taught Gurmat Sangeet at Gurmat Gian Missionary College, Jawadi, Ludhiana. Elder child to Pushpinder Kaur and Dr. Brig. Harminder Singh, was born in Amritsar on 13th Jan 1962. She attended various convent schools as a child because her father would get frequent Army postings as a dental surgeon. She graduated with Music Honors from Govt. College for Women, Chandigarh. Music was her hobby and she composed and sang Raag based Gurbani Shabads. Doing Kirtan was part of growing up nurtured by her parents. She learned music from her father Dr. Brigadier Harminder Singh who was a dental surgeon in Indian Army and a very good singer himself. Gurpreet’s Bhua (father’s sister), Ajit Kaur retied as a Head of Department of Music from Govt. College for Women Ludhiana, and was a renounced Punjabi singer of her time. Gurpreet Kaur also learned nuances of Indian Classical Music from Pandita Sharma. She was a mother of three children, and a grandmother. Her daughter Keerat Kaur is a Computer Engineer. Her two sons Gurkeerat Singh and Jaskeerat Singh are doctors in USA. Her daughter Keerat Kaur too was part of her group ~ Gurmat Gian Group. Gurpreet Kaur left this world at the age of 54yrs on 12th Sept 2016 in Baltimore USA. She had recorded around 25 cds of Gurbani Keertan. 'Raag Ratan' Album (6 CDs) is a Compilation of Shabads in All the 31 Sudh Raags of Sri Guru Granth Sahib Ji. 'Gauri Sagar' Album (3 CDs) is a Compilation of All forms of Raag Gauri in Sri Guru Granth Sahib Ji. 'Nanak Ki Malhaar' ~ ((3 CDs) is an album of Raag Malhar Shabads in various forms of Malhar. 'Gur Parsaad Basant Bana' ~ (3 CDs) is an album of Shabads in Raag Basant sung in various forms of Raag Basant. Har Ki Vadeyai Sarni Aayea Sewa Priya Kee Preet Piyaree Mohan Ghar Aavho Karo Jodariya Mo Kao Taar Le Raama Taar Le Tere Kavan Kavan Gun Keh Keh Gawan Mera Baid Guru Govinda Saajanrraa Mera Saajanrraa

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